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It was first synthesized in the 1990s, based on the amino acid composition of epithalamin, a peptide extract derived from the bovine pineal gland

In vertebrates, melanin is formed from a precursor of L-tyrosine, which undergoes a series of spontaneous reactions in the Raper-Mason pathway to synthesize the pigment

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The interactions between the gut microbiota and the brain involve multiple intricate pathways